The classification criteria were derived from a set of 702 expertrated patient scenarios. Sle or lupus for short is a multisystem, autoimmune disease, involving. Under this proposal the patient must meet at least 4. Systemic lupus erythematosus sle is a chronic autoimmune disease characterised by multisystem manifestations. Navarra sv, guzman rm, gallacher ae, hall s, levy ra, jimenez re, li ekm, thomas m, kim hy, leon mg, tanasescu c, nasonov e, lan jl, pinela l, zhong zj, freimuth w, petri ma. Jan 19, 2018 san diegoproposed classification criteria for systemic lupus erythematosus sle, which are supported but not yet approved by the acr and eular, debuted on nov.
Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Pdf 2015 acrslicc revised criteria for diagnosis of. The performances of the acr 1997, slicc 2012, and eular. For the slicc criteria, criteria are cumulative and need not be presently concurrently. Application of the 2012 systemic lupus international collaborating. We included 243 confirmed sle patients who met the 1982 american college of rheumatology acr82 classification criteria andor the fries. Both the 19821997 acr classification criteria and the 2012 slicc criteria defined exclusion criteria for various items. A detailed comparison of the classification criteria from 1971, 1982, 1997 and 2012 is depicted in the table below. In 2012, petri and magder published a study about the derivation and validation of slicc criteria for sle classification. Translated into norwegian based on english version3 slicc criteria for sle 2012 4 acr criteria for sle 1997 definition the criteria are classification criteria used in research. In 2012, the systemic lupus international collaborating clinics slicc validated new sle classification criteria through a series of consensus exercises using symptomatology and laboratory results drawn from real rheumatologic cases. Most of its pathology is mediated by either direct or indirect effects of these autoantibodies. Slicc criteria for sle slicc classification criteria for.
New 2019 sle eularacr classification criteria are valuable. Systemic lupus erythematosus symptoms, diagnosis and. To examine the sensitivity of the 2 sets according to disease duration, we categorized the study population into 5 subgroups from disease onset to enrollment in this study up to 5 years. The diagnostic accuracies of the 2012 slicc criteria and the proposed eularacr criteria for systemic lupus erythematosus classification are comparable. Diagnostic criteria for systemic lupus erythematosus.
We have now compared both sets of criteria in a wellcharacterized sle cohort. Derivation and validation of systemic lupus international. According to the slicc rule for the classification of sle, the patient must satisfy at least 4 criteria, including at least one clinical criterion and one immunologic criterion or the patient m. Performance of the proposed acr eular classification criteria. Performance of the proposed acreular classification. Different classification criteria for systemic lupus erythematosus sle have been proposed over many years. Pdf the diagnostic accuracies of the 2012 slicc criteria and the. A comparison between the classification criteria for sle slicc 2012 acr 1997 acr 1982 ara 1971 clinical criteria 1. Evidence based medicine slicc criteria for sle cmi. Three sets of lupus criteria sle acr1997, sle slicc and 2019 sle eularacr criteria were tested in each group of patients. Lupus international collaborating clinics slicc classification criteria for systemic lupus erythematosus. Systemic lupus erythematosus, its treatment, and future. The slicc 2012 criteria may allow patients to be classi. The criteria for sle using acr 97 requires that the patient present four of the eleven criteria, but the slicc revised and validated those criteria in 2012 proposing that the patient meet four of the seventeen criteria being at least one clinical criterion and one criterion included in the diagnosis.
Classification criteria sle eular acr 2018, slicc 2012. Comparison between three systems of classification. Systemic lupus diagnostic criteria slicc calculator. However, their specificity for sle appeared to be lower compared with acr82. Comparison between three systems of classification criteria. In a joint effort, the european league against rheumatism eular and the american college of rheumatology acr recently proposed new criteria for the classification of systemic lupus erythematosus sle with the overarching goal to identify potential participants for clinical studies. Sle is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Slicc classification criteria for sle current medical. Racgp systemic lupus erythmatosus when to consider and. Nephritis introduction in several ways, systemic lupus erythematosus sle is a rather unusual disease. Performance of the proposed acreular classification criteria.
This study aims to compare the performance among the american college of rheumatology acr 1997, the systemic lupus international collaborating clinics criteria slicc and the new european league against rheumatism eularacr criteria, in a csle cohort. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc12 to classify systemic lupus erythematosus sle. Application of the 2012 systemic lupus international. The 1982 revised criteria for the classification of systemic lupus erythematosus. Lupus nephritis is a major risk factor for overall morbidity and mortality in sle, and despite potent antiinflammatory and immunosuppressive therapies still ends in ckd or esrd for too many patients. Jan 10, 2015 introduction in 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc12 to classify systemic lupus erythematosus sle. We would like to show you a description here but the site wont allow us. You might also like new classification criteria for sle. The 2012 revised slicc criteria for classification of. Table 1 demographics of subjects with sle and ile based on 2012 slicc and 1997 acr criteria sle slicconly n178 sle acronly n85 sle both n3312 ile n291 sex. In 2012, the systemic lupus collaborating clinics proposed the slicc criteria for sle in view of new knowledge of autoantibodies and the importance of low complement. The thorough heterogeneity among patients with systemic lupus erythematosus sle causes problems regarding diagnostic accuracy in clinical. We therefore attempted to enrich our sample populations for early sle in. Update on lupus nephritis american society of nephrology.
The revised immunologic criteria reflect new insights into sle serology and take into account the wider use of elisa assays. Jul 14, 2014 a detailed comparison of the classification criteria from 1971, 1982, 1997 and 2012 is depicted in the table below. New lupus classification criteria presented at acrarhp. The present study is the first to evaluate the performance of slicc12 in an adult european study population. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. The recent attempts to create modern criteria for the classi. The slicc 2012 criteria were more sensitive than the acr 1997 criteria in reallife clinical practice in sle. In this populationbased study, the incidence of sle was higher and time to criteria fulfillment sooner by 2019 eularacr criteria compared to the 1997 acr but not significantly different than the 2012 slicc criteria. Classification criteria for systemic lupus erythematosus sle have been developed to ensure the inclusion of homogeneous groups of patients in. Slicc criteria for sle slicc classification criteria for sle.
Validation of the 2017 weighted criteria compared to the 1997. Systemic lupus erythematosus sle is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. Slicc criteria requires either that a patient satisfy at least 4 of 17 criteria, including at least 1 of the 11 clinical criteria and one of the six immunologic criteria, or that the patient has biopsyproven nephritis compatible with sle in the presence of antinuclear antibodies ana or antidoublestranded dna dsdna antibodies.
In 2012, the systemic lupus international collaborating clinics slicc developed and validated new sle classification criteria. May 15, 2019 to date there are no specific classification criteria for childhoodonset systemic lupus erythematosus csle. Future biomarkers may be useful in distinguishing sle from other diseases and in monitoring of disease activity. New classification system for systemic lupus erythematosus. The most widely used and accepted criteria has been the 1997 acr criteria. What are eularacr diagnostic criteria for systemic lupus. Use of slicc criteria in a large, diverse lupus registry. Pdf in an early sle cohort the acr1997, slicc2012 and. Comparison among acr1997, slicc and the new eularacr. Jul 20, 2017 there are currently two classification criteria in use. Familiarity with the diagnostic criteria helps clinicians to recognize sle and to subclassify this complex disease based on the pattern of targetorgan manifestations.
May, 2020 classification criteria define the patient population for clinical trials and translational studies, but also influence current understanding of the disease. Clinical criteria acute cutaneous lupus or subacute cutaneous lupus. Derivation and validation of the systemic lupus international. The slicc group has proposed a modification of the revisedupdated sle acr classification criteria. Classification criteria for systemic lupus erythematosus. For each subgroup, the sensitivity of the acr 1997 and slicc 2012 classi. It is regarded as the prototypal connective tissue disease, 1 where the key pathogenesis relates to a dysfunctional immune system that results in overproduction of various autoantibodies. In an early sle cohort the acr1997, slicc2012 and eular. Updating the american college of rheumatology revised criteria for the classification of systemic lupus erythematosus letter. The new slicc classification criteria performed well in a large set of patient scenarios rated by experts. Include cytoid bodies, retinal hemorrhages, serious exodate or hemorrhages in the choroids, or optic neuritis. In september 2019, the european league against rheumatism eular and the american college of rheumatology acr published new criteria for the classification of sle.
Systemic lupus erythematosus sle, is the most common type of lupus. The diagnostic accuracies of the 2012 slicc criteria and the. Introduction systemic lupus erythematosus sle poses great challenges. Thus, slicc12 criteria were applied to confirmed sle cases in our regional sle register as well as to. The slicc criteria for sle classification requires. Pdf objectives classification criteria are biased towards classifying long standing disease. Slicc 12 criteria are more effectiveness than acr 97 score. Pdf the diagnostic accuracies of the 2012 slicc criteria. Age and sex adjusted incidence rates by different sle classification criteria from 20002018. We included 56 confirmed sle cases meeting the 1982 acr criteria acr82 andor the fries diagnostic principle antinuclear antibodies on at least one occasion plus involvement of at least two defined organ systems and 55 controls with possible systemic autoimmune disease, including the presence of any slerelated autoantibody. Incidence and time to classification of systemic lupus.
Acute cutaneous le acute cutaneous le 6 or scle scle 4 2. Table 1 single criteria in the four sle classification criteria sets since 1982 acr 1982 acr 1997 slicc 2012 eularacr 2019 mucocutaneous 1. Comparing the 1997 update of the 1982 american college of. The diagnostic accuracies of the 2012 slicc criteria and. New understandings of sle pathogenesis have rendered the 1982 acr criteria outdated, according to a recently published paper arthritis care res.
There were no significant differences in sensitivity and specificity between the 2012 slicc and the 2017 weighted criteria. A patient is classified as having sle if he or she satisfies 4 of the clinical and immunologic criteria used in the slicc classification criteria, including at least 1 clinical criterion and 1 immunologic criterion. Mar 18, 2020 the diagnosis of systemic lupus erythematosus sle must be based on the proper constellation of clinical findings and laboratory evidence. Sle is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria. Pdf 2015 acrslicc revised criteria for diagnosis of systemic. The 2017 weighted and 2012 slicc were more sensitive than the 1997 acr criteria. Validation of the 2017 weighted criteria compared to the. Th e extreme heterogeneity of the disease has led some investigators to propose that sle represents a syndrome rather than a single disease. Diagnosis and management of systematic lupus erythematosus sle. Pdf on apr 20, 2015, iraj salehi abari published 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus find, read and cite all the research you need on researchgate.
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